Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Picroside-I attenuated isoproterenol-induced heart damage via modification of cardio-morphology, infarct size and inflammatory cascade

Yi Hao¹ , Zhixiong Cui¹, Shuang Zhang², Tong Liu²

¹Department of Cardiac Surgery; ²Department of Radiology, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China.

For correspondence:- Yi Hao Email: hythia@yahoo.com Tel:+861069543901

Accepted: 26 January 2020 Published: 30 April 2020

Citation: Hao Y, Cui Z, Zhang S, Liu T. Picroside-I attenuated isoproterenol-induced heart damage via modification of cardio-morphology, infarct size and inflammatory cascade. Trop J Pharm Res 2020; 19(4):781-788 doi: 10.4314/tjpr.v19i4.15

© 2020 The authors.
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Abstract

Purpose: To study the effect of picroside-I (PIC-I) on isoproterenol (ISO)-induced heart damage in rats through determination of infarct size, antioxidant enzymes, cardiac/inflammatory and apoptotic markers, as well as cardio-morphology.

Methods: A total of 32 rats were divided equally into 4 groups. Rats in normal control group were treated with saline only, while myocardial infarction (MI) rat model was prepared by intraperitoneal (i.p.) injection of ISO at a concentration of 100 mg/kg. Rats pretreated with PIC-Iat dose 10 mg/kg (i.p) for 28 days and administered with isoproterenol. Another group of rats was administered only with PIC-I (10 mg/kg) for 28 days.

Results: After 28 days of pretreatment with PIC-I, there were significant increases in arterial blood pressure and cardiac antioxidants, as well as marked decreases in infarct size, cardiac markers, inflammatory markers and apoptotic markers in rats with ISO-induced heart damage, when compared with rats given ISO alone. Rats administered PIC-I showed better histology, with reduced necrosis and prominent cardiac fibers.

Conclusion: PIC-1 pre-treatment for 28 days significantly reversed elevations in infarct size, cardiac/inflammatory and apoptotic markers, and also improved antioxidant status and cardiac morphology in rats with ISO-induced heart damage.

Keywords: Picroside-I, Isoproterenol, Infarct size, Inflammation, Apoptosis